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Hassle-free Microscopy Manager -

HMM for Laser Scanning Microscopies

Hassle-free Microscopy Manager -

HMM for Laser Scanning Microscopies

Unlock the Future of Laser Scanning Microscopy with Seamless Integration

Building a high-performance laser scanning microscope shouldn't require building everything from scratch. Researchers and developers often struggle with hardware and software integration, image quality, and synchronization and real-time image data transfer and processing. We built the Hassle-Free Microscopy Manager to change that.


The HMM-SC 8100 is a groundbreaking PCIe and FPGA-based solution that eliminates traditional barriers for researchers and innovators developing their own laser scanning microscopy systems. This state-of-the-art card empowers users to build and customize systems with ease, allowing them to focus entirely on their research ideas and applications without unnecessary hassles. Applicable across confocal, multi-photon, Minflux, SRS, CARS, CDM and photoacoustic microscopy—it sets a new benchmark for precision, image performance, and usability.

Contact Us

Key Features & Benefits

  • Seamless Hardware Synchronization:  Integrate PMTs, resonant scanners, galvos, lasers, and control modules effortlessly. → HMM Simplifies multi-component setup and minimizes timing errors across channels, ensuring a seamless and efficient workflow.
  • Ultra-Fast Signal Acquisition (1GS/s): Digitize high-bandwidth signals with exceptional signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR).→ Enables: 1.Higher dynamic range 2.High-speed, streamlined data processing 3.Superior-quality bioimages for advanced research
  • Precision Analog and Digital I/O: Full-range analog/digital control with 16-bit resolution and up to 9 TTL channels → Coordinate complex scanning protocols with confidence.
  • Plug-and-Play PCIe Architecture: With a standardized form factor and ultra-light host PC load, integration is seamless→ no full system rebuild needed. The host PC’s role is streamlined to image data reception and display only.
  • Tailored for Advanced Modalities Compatible with Confocal, Multi-photon, Minflux, SRS, CARS, CDM and Photoacoustic systems → One card for all your advanced imaging needs.

Who It’s For & How It Helps

√ Ideal for :  Research labs developing custom or modular microscopes

√ OEMs building high-end life science imaging systems

√ Interdisciplinary projects requiring signal synchronization and control

Whether you're designing next-gen imaging techniques or upgrading legacy systems, HMM-SC 8100 accelerates your workflow while preserving flexibility.


Contact Us 

Discover how the Hassle-Free Microscopy Manager can elevate your research. Contact us today to learn more or request a demonstration.

Table 1 : HMM for Laser Scanning Microscopy Control Card



Analog input
  • Bit Resolution: 16-bit
  • Channel Number: 4 channels
  • Signal Type: Differential
  •  Sampling Rate: 1GS/s
  • Range: +/- 250mV


Analog output

  • Bit Resolution: 14-bit
  • Channel Number: 4 channels
  • Sampling Rate: 1MS/s
  • Range: +/- 10V


Constant Analog output

  • Bit Resolution: 10-bit
  • Channel Number: 8 channels
  • Range: +/- 10V


Digital IO


  • Channel Number: 4 channels
  • Signal Type: TTL

 
Trigger input

  • Channel Number: 1 channels
  • Signal Type: TTL
  • Clock: 100MHz

 
Trigger output

  • Channel Number: 9 channels
  • Signal Type: TTL
  • Clock: 100MHz

Bus Standard

  • PCIe

 
Connector


  • Analog input SMB x4
  • SCSI – 28pin connector

On Board Memory

  • 4GB


Table 2 : Connector Block



Driving Analog Output
  • BNC x4
  • X-Galvo Driving
  • Y-Galvo Driving
  • Resonant Driving
  • Piezo Z Driving

Detector Input

  • SMB x4

​Detector Gain Output

  • BNC x4

​Laser Power Control

  • BNC x4

 ​Marker Input

  • BNC x4

 ​Resonant Trigger Input

  • BNC



Trigger Output

  • BNC x4
  • Frame Trigger
  • Line Trigger
  • Pixel Clock
  • User Define


Table 3 : Software

Scanning Resolution
  • Galvo-Galvo: 64x64 to 4096x4096
  • Resonance-Galvo: 128x128 to 2048x2048

Controls

  • Laser Analog Control
  • Detector Gain Control

​Scanning Method

  • XY, XYZ, XYT, XYZT


Frame Rate

  • Galvo-Galvo: up to 1fps @512x512 uni-directional scan
  • Resonance-Galvo: up to 16fps @512x512 uni-directional scan with 8kHz resonance scanner

 ​Display Channels

  • Up to 4-ch

 ​Display Modes

  • Split modes
  • Color modes

Software Develop Kit

  • DLL Library  


Table 4 : Others

Cables
  • ​SMB-BNC 2m x4
  • SCSI 28pin Cable 2m

Connector Power  

  • 100-240 VAC to DC Adaptor 



Computer Requirement

  • CPU: Intel I5 or higher
  • RAM: 16 GB or higher
  • HDD: SSD 512 GB or higher
  • OS: Windows 11 or higher
  • With 1 PCIe Gen.4 x8 slot
  • Graphic Card: T400 or Higher



Introducing HMM — a Breakthrough Card for Laser Scanning Microscopy ​​
Eliminate Imaging Trade-Offs: Discover TLI-HMM’s 1GS/s Power ​​
Build Your Own High-Performance Laser Scanning Microscope — Without the Engineering Headaches
Frustrated by noisy microscopy images? 
Still reconstructing images offline?
Why sampling rate matters in LSM (and how 1GS/s changes everything)


Contact us for more information​​
The Significance of HMM to Laser Scanning Microscopies Developers ​​

Seamless Integration for Fast and High-quality Imaging

Revolutionize Laser Scanning Microscopy—Without Rebuilding Everything​

Building a high-performance laser scanning microscope shouldn't require building everything from scratch. Researchers and developers often struggle with hardware and software integration, image quality, synchronization and real-time image data transfer and processing. We built the Hassle-Free Microscopy Manager to change that.


The HMM-SC 8100 is a groundbreaking PCIe and FPGA-based solution that eliminates traditional barriers for researchers and innovators developing their own laser scanning microscopy systems. This state-of-the-art card empowers users to build and customize systems with ease, allowing them to focus entirely on their research ideas and applications without unnecessary hassles. Applicable across confocal, multi-photon, STED, TIRF, SNOM, and photoacoustic microscopy—it sets a new benchmark for precision, image performance, and usability.

​

Contact Us

Key Features & Benefits

  • Seamless Hardware Synchronization: Integrate PMTs, resonant scanners, galvos, lasers, and control modules effortlessly. → HMM Simplifies multi-component setup and minimizes timing errors across channels, ensuring a seamless and efficient workflow.
  • Ultra-Fast Signal Acquisition (1GS/s): Digitize high-bandwidth signals with exceptional signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR).→ Enables: 1.Higher dynamic range 2.High-speed, streamlined data processing 3.Superior-quality bioimages for advanced research
  • Precision Analog and Digital I/O: Full-range analog/digital control with 16-bit resolution and up to 9 TTL channels → Coordinate complex scanning protocols with confidence.
  • Plug-and-Play PCIe Architecture: With a standardized form factor and ultra-light host PC load, integration is seamless→ no full system rebuild needed. The host PC’s role is streamlined to image data reception and display only.
  • Tailored for Advanced Modalities: Compatible with Confocal, Multi-photon, STED, TIRF, SNOM, and Photoacoustic systems → One card for all your advanced imaging needs.


Who It’s For & How It Helps

Ideal for : 

√ Research labs developing custom or modular microscopes

√ OEMs building high-end life science imaging systems

√ Interdisciplinary projects requiring signal synchronization and control

Whether you're designing next-gen imaging techniques or upgrading legacy systems, HMM-SC 8100 accelerates your workflow while preserving flexibility.


Contact Us 

Discover how the Hassle-Free Microscopy Manager can elevate your research. Contact us today to learn more or request a demonstration.

Table 1 : HMM for Laser Scanning Microscopy Control Card



Analog input
  • Bit Resolution: 16-bit
  • Channel Number: 4 channels
  • Signal Type: Differential
  •  Sampling Rate: 1GS/s
  • Range: +/- 250mV


Analog output

  • Bit Resolution: 14-bit
  • Channel Number: 4 channels
  • Sampling Rate: 1MS/s
  • Range: +/- 10V


Constant Analog output

  • Bit Resolution: 10-bit
  • Channel Number: 8 channels
  • Range: +/- 10V


Digital IO


  • Channel Number: 4 channels
  • Signal Type: TTL

 
Trigger input

  • Channel Number: 1 channels
  • Signal Type: TTL
  • Clock: 100MHz

 
Trigger output

  • Channel Number: 9 channels
  • Signal Type: TTL
  • Clock: 100MHz

Bus Standard

  • PCIe

 
Connector


  • Analog input SMB x4
  • SCSI – 28pin connector

On Board Memory

  • 4GB


Table 2 : Connector Block



Driving Analog Output
  • BNC x4
  • X-Galvo Driving
  • Y-Galvo Driving
  • Resonant Driving
  • Piezo Z Driving

Detector Input

  • SMB x4

​Detector Gain Output

  • BNC x4

​Laser Power Control

  • BNC x4

 ​Marker Input

  • BNC x4

 ​Resonant Trigger Input

  • BNC



Trigger Output

  • BNC x4
  • Frame Trigger
  • Line Trigger
  • Pixel Clock
  • User Define


Table 3 : Software

Scanning Resolution
  • Galvo-Galvo: 64x64 to 4096x4096
  • Resonance-Galvo: 128x128 to 2048x2048

Controls

  • Laser Analog Control
  • Detector Gain Control

​Scanning Method

  • XY, XYZ, XYT, XYZT


Frame Rate

  • Galvo-Galvo: up to 1fps @512x512 uni-directional scan
  • Resonance-Galvo: up to 16fps @512x512 uni-directional scan with 8kHz resonance scanner

 ​Display Channels

  • Up to 4-ch

 ​Display Modes

  • Split modes
  • Color modes

Software Develop Kit

  • DLL Library  


Table 4 : Others

Cables 
  • ​SMB-BNC 2m x4
  • SCSI 28pin Cable 2m

Connector Power  

  • 100-240 VAC to DC Adaptor 



Computer Requirement

  • CPU: Intel I5 or higher
  • RAM: 16 GB or higher
  • HDD: SSD 512 GB or higher
  • OS: Windows 11 or higher
  • With 1 PCIe Gen.4 x8 slot
  • Graphic Card: T400 or Higher
Introducing HMM — a Breakthrough Card for Laser Scanning Microscopy
Eliminate Imaging Trade-Offs: Discover TLI-HMM’s 1GS/s Power
Build Your Own High-Performance Laser Scanning Microscope — Without the Engineering Headaches
Frustrated by noisy microscopy images?
Still reconstructing images offline?
Why sampling rate matters in LSM (and how 1GS/s changes everything)
Contact us for more information​​

Performance​ Showcase



Images of Neonatal Mouse Brain Slice Using HMM and Digitizer - 2 Photon Microscopy



(Mouse Brain Tissue + GFP)



Images of BPAE Cells Using HMM and Digitizer - 2 Photon Microscopy


(Phalloidin + Alexa Fluor 488 Mitochondria + Red CMXRos) 

How 1GS/s Improves the Image Quality

(Mouse Brain Tissue + GFP)


Images of Neonatal Mouse Brain Slice Using HMM and Digitizer - 2 Photon Microscopy

(Phalloidin + Alexa Fluor 488 Mitochondria + Red CMXRos) 


Images of BPAE Cells Using HMM and Digitizer - 2 Photon Microscopy

How 1GS/s Improves the Image Quality

Quantitative Analysis on SNR with/without HMM

Quantitative Analysis on CNR with/without HMM

Quantitative Analysis on SNR with/without HMM

Quantitative Analysis on CNR with/without HMM